Job Information

Sandia National Laboratories Postdoctoral Appointee - Virology/Immunology and Antiviral Therapies in Livermore, California

Posting Duration:

This posting will be open for application submissions for a minimum of seven (7) calendar days, including the ‘posting date’. Sandia reserves the right to extend the posting date at any time.

What Your Job Will Be Like:

Are you looking to do creative and worthwhile research? Do you want to increase your engagement with research that protects the population from emerging infectious diseases and prepares us to respond to future threats? Come and join Sandia/California’s Systems Biology Department! We are seeking a highly dedicated and hardworking virologist/molecular biologist/immunologist postdoctoral appointee to develop powerful antiviral therapies against viruses such as influenza hemagglutinin, neuraminidase, and SARS-CoV-2. The selected applicant will help develop and implement assays to characterize host-pathogen interactions that influence transmission, virulence, and immune evasion and work on a yeast cell surface display system for isolating and engineering antibodies and antigens (working with project PI)

On any given day, you may be called on to:

  • Participate in the national response to the pandemic and emerging biothreats

  • Develop and implement assays to characterize host-pathogen interactions to test against multiple virus models

  • Perform experiments to design, engineer, produce and characterize next-generation antibodies and other engineered protein constructs

  • Mentor technologists and interns

  • Work to execute, track and refine project plans with an integrated multidisciplinary team that may include members from national labs, universities, and industry

  • Publish scientific papers in peer-reviewed journals and present findings at seminars and conferences

Qualifications We Require:

  • PhD in virology, immunology, microbiology, biochemistry, molecular biology, cell biology, biology, or a related field

  • Familiarity with tasks common in a virology laboratory, including knowledge of techniques and basic safety procedures in BSL2 (or higher) environment and proper storage and handling of viruses

  • Experience with molecular biology techniques (e.g., PCR, primer design, molecular cloning, and gene synth) and immunoassays

  • Proven record of high technical accomplishment and written communication (e.g. as evidenced by publication in high-impact scientific journals) and strong verbal communication and data presentation skills (e.g., as demonstrated through scientific conference presentations)

Qualifications We Desire:

  • Experience with reverse genetics and genome engineering technologies (e.g. CRISPR)

  • Experience with protein display, phage display or directed evolution methods

  • Experience in high-throughput assay development, mass spectrometry, or next-generation sequencing

  • Experience in animal models of disease and basic animal handling, including dose refinement, measurement of host response, and protection against challenges

  • Bioinformatics or computational biology skills and familiarity with related software tools, (e.g., next-generation sequencing analysis, antibody, and protein design)

  • Eligibility to obtain a US Department of Energy security clearance

About Our Team:

The Biotechnology and Bioengineering Department, located in Livermore, CA, performs both basic and applied biological and bioengineering research with broad applications in national security, biodefense, health security, climate, and energy security. Our research in virology, microbiology, immunology and bioinformatics, is addressed by advanced technology development including CRISPR/Cas technologies, antibody engineering, advanced omics, synthetic biology, and advanced materials and nanotechnology. Our department is integrated into the highly multidisciplinary Applied Biosciences and Engineering Group, comprised of researchers with expertise in many disciplines of biology (molecular biology, microbiology, virology, immunology and biochemistry), chemistry (analytical, organic and physical), computational science (bioinformatics, machine learning, computational chemistry), and engineering (chemical, mechanical and biomedical).

About Sandia:

Sandia National Laboratories is the nation’s premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a broad array of areas. Some of the main reasons we love our jobs:

  • Challenging work with amazing impact that contributes to security, peace, and freedom worldwide

  • Extraordinary co-workers

  • Some of the best tools, equipment, and research facilities in the world

  • Career advancement and enrichment opportunities

  • Flexible work arrangements for many positions include 9/80 (work 80 hours every two weeks, with every other Friday off) and 4/10 (work 4 ten-hour days each week) compressed workweeks, part-time work, and telecommuting (a mix of onsite work and working from home)

  • Generous vacations, strong medical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance*

World-changing technologies. Life-changing careers. Learn more about Sandia at: http://www.sandia.gov*These benefits vary by job classification.

Security Clearance:

This position does not currently require a Department of Energy (DOE) security clearance.

Sandia will conduct a pre-employment drug test and background review that includes checks of personal references, credit, law enforcement records, and employment/education verifications. Furthermore, employees in New Mexico need to pass a U.S. Air Force background screen for access to Kirtland Air Force Base. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause access to be denied or terminated, resulting in the inability to perform the duties assigned and subsequent termination of employment.

If hired without a clearance and it subsequently becomes necessary to obtain and maintain one for the position, or you bid on positions that require a clearance, a pre-processing background review may be conducted prior to a required federal background investigation. Applicants for a DOE security clearance need to be U.S. citizens. If you hold more than one citizenship (i.e., of the U.S. and another country), your ability to obtain a security clearance may be impacted.

Members of the workforce (MOWs) hired at Sandia who require uncleared access for greater than 179 days during their employment, are required to go through the Uncleared Personal Identity Verification (UPIV) process. Access includes physical and/or cyber (logical) access, as well as remote access to any NNSA information technology (IT) systems. UPIV requirements are not applicable to individuals who require a DOE personnel security clearance for the performance of their SNL employment or to foreign nationals. The UPIV process will include the completion of a USAccess Enrollment, SF-85 (Questionnaire for Non-Sensitive Positions) and OF-306 (Declaration of for Federal Employment). An unfavorable UPIV determination will result in immediate retrieval of the SNL issued badge, removal of cyber (logical) access and/or removal from SNL subcontract. All MOWs may appeal the unfavorable UPIV determination to DOE/NNSA immediately. If the appeal is unsuccessful, the MOW may try to go through the UPIV process one year after the decision date.

EEO:

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, or veteran status and any other protected class under state or federal law.

Position Information:

This postdoctoral position is a temporary position for up to one year, which may be renewed at Sandia's discretion up to five additional years. The PhD must have been conferred within five years prior to employment.

Individuals in postdoctoral positions may bid on regular Sandia positions as internal candidates, and in some cases may be converted to regular career positions during their term if warranted by ongoing operational needs, continuing availability of funds, and satisfactory job performance.

Job ID: 686224